| Identification | Back Directory | [Name]
ONO-LB 457 | [CAS]
134578-96-4 | [Synonyms]
ONO-4057
ONO-LB 457
Benzenepropanoic acid, 2-(4-carboxybutoxy)-6-[[(5E)-6-(4-methoxyphenyl)-5-hexen-1-yl]oxy]- | [Molecular Formula]
C27H34O7 | [MDL Number]
MFCD00913369 | [MOL File]
134578-96-4.mol | [Molecular Weight]
470.55 |
| Chemical Properties | Back Directory | [Boiling point ]
704.8±60.0 °C(Predicted) | [density ]
1.173±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
4.68±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
ONO4057 is a Leukotriene B4 receptor antagonist, with an IC50 of 0.7±0.3 μM. | [in vivo]
Mean animal survivals of the ONO4057-treated animals significantly prolong to 21.0±4.4 days compare with 12.0±0.6 days in control group. Histological findings from grafts taken on day 7 show that severe focal cellular infiltration is observed in both groups, but the degree of hepatocyte necrosis in ONO4057-treated anmimals is milder than that in control group[2]. | [IC 50]
LTB4: 0.7 μM (IC50) | [storage]
Store at -20°C | [References]
[1] Kishikawa K, et al. ONO-4057, a novel, orally active leukotriene B4 antagonist: effects on LTB4-induced neutrophil functions. Prostaglandins. 1992 Oct;44(4):261-75. DOI:10.1016/0090-6980(92)90002-b
[2] Tanaka M, et al. Effect of leukotriene B(4) receptor antagonist (ONO4057) on hepatic allografting in rats. Transplant Proc. 2000 Nov;32(7):2340. DOI:10.1016/s0041-1345(00)01690-0 |
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