| Identification | Back Directory | [Name]
(S)-1-(3-BROMOPHENYL)ETHANOL | [CAS]
134615-22-8 | [Synonyms]
(S)-1-(3-BROMOPHENYL)ETHANOL
(1S)-1-(3-Bromophenyl)ethanol
(S)-3-Bromo-α-methylbenzyl alcohol
(S)-α-Methyl-3-bromobenzyl alcohol
(S)-α-Methyl-3-bromobenzenemethanol
(S)-3-BROMO-ALPHA-METHYLBENZYL ALCOHOL
(alphaS)-3-Bromo-alpha-methylbenzenemethanol
(S)-3-Bromo-alpha-methylbenzyl alcohol, 98% ee, 95%
(S)-3-Bromo-alpha-methylbenzyl alcohol, 95%, ee:98%
(S)-3-Bromo-alpha-methylbenzyl alcohol, 95% (98% e.e.) | [Molecular Formula]
C8H9BrO | [MDL Number]
MFCD06201859 | [MOL File]
134615-22-8.mol | [Molecular Weight]
201.06 |
| Chemical Properties | Back Directory | [Appearance]
clear colorless liquid | [Boiling point ]
264℃ | [density ]
1.470 | [Fp ]
114℃ | [storage temp. ]
2-8°C | [form ]
Liquid | [pka]
14.35±0.20(Predicted) | [color ]
Clear colorless |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless liquid | [Synthesis]
General procedure for the synthesis of 1-(3-bromophenyl)ethanol and (S)-1-(3-bromophenyl)ethanol from 3'-bromoacetophenone: under dry argon protection, the catalyst [0.4 mol% (complexes 12-22) or 0.2 mol% (dinuclear complex 24)] and 3'-bromoacetophenone (2.5 mmol) were added to a three necked Schlenk flask. The mixture was stirred at 82 °C for 15 min before adding 5 mL of a 0.06 M solution of base (Cs2CO3) in 2-propanol (0.3 mmol). The reaction progress was monitored by an HP-6890 gas chromatograph. In all reactions, only the corresponding alcohols and ketones were detected as products. Conversion rates and enantiomeric excess values (e.e. values) were determined by gas chromatography using a Supelco β-DEX 120 chiral capillary column. | [References]
[1] Molecular Catalysis, 2018, vol. 456, p. 75 - 86
[2] Tetrahedron Letters, 2018, vol. 59, # 8, p. 719 - 722
[3] Angewandte Chemie, 1995, vol. 107, # 18, p. 2165 - 2166
[4] Angewandte Chemie, 1995, vol. 107, # 18, p. 2165 - 2166
[5] Journal of Organometallic Chemistry, 1997, vol. 547, # 1, p. 97 - 101 |
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