| Identification | Back Directory | [Name]
2'-cyano-2'-deoxyarabinofuranosylcytosine | [CAS]
134665-72-8 | [Synonyms]
TAS109
TAS 109
CNDAC HCl
CNDAC HCl salt
CNDAC hydrochloride
TAS-109 Hydrochloride
DFP-10917 Hydrochloride
2'-cyano-2'-deoxyarabinofuranosylcytosine
2'-Cyano-2'-deoxyarabinofuranosylcytosine hydrochloride
1-(2-C-cyano-2-deoxy-β-D-arabinofuranosyl)cytosine hydrochloride
DFP-10917 HYDROCHLORIDE; TAS-109 HYDROCHLORIDE;CNDAC;TAS109;TAS 109
(2R,3S,4S,5R)-2-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-carbonitrile hydrochloride | [Molecular Formula]
C10H12N4O4*ClH | [MOL File]
134665-72-8.mol | [Molecular Weight]
288.69 |
| Hazard Information | Back Directory | [Uses]
CNDAC hydrochloride is a metabolite of the orally active agent Sapacitabine.html" class="link-product" target="_blank">Sapacitabine (HY-16445), and a nucleoside analog. CNDAC hydrochloride induces DNA damage and apoptosis[1][2]. | [in vivo]
CNDAC (20mg/kg; i.p.; daily for 10 days) shows antitumor activity in mice[4]. | Animal Model: | CDF1 mice, P388 tumor model[4] | | Dosage: | 20 mg/kg | | Administration: | Intraperitoneal injection, daily for 10 days | | Result: | Greatly increased the survival time and survival rate. |
| [storage]
Store at -20°C | [References]
[1] Liu XJ, et al. Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks. Chin J Cancer. 2012 Aug;31(8):373-80. DOI:10.5732/cjc.012.10077
[2] Jagan S, et al. Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of Sapacitabine. Adv Hematol. 2012;2012:727683. DOI:10.1155/2012/727683
[3] Serova M, et al. Antiproliferative effects of sapacitabine (CYC682), a novel 2'-deoxycytidine-derivative, in human cancer cells. Br J Cancer. 2007 Sep 3;97(5):628-36. DOI:10.1038/sj.bjc.6603896
[4] Azuma A, et al. Nucleosides and nucleotides. 122. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum. J Med Chem. 1993 Dec 24;36(26):4183-9. DOI:10.1021/jm00078a006 |
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