| Identification | Back Directory | [Name]
MPEG-SH | [CAS]
134874-49-0 | [Synonyms]
mPEG-SH
mPEG2K-SH
PEG-THIOL
mPEG12-thiol
mPEG-SH,MW:20000
MEO-DPEG(TM)(12)-SH
MPEGn-SH 2K, 5K, 10K, 20K
O-(2-Mercaptoethyl)-O′-methylpolyethylene glycol
Polyethylene glycol 2-mercaptoethyl methyl ether
Poly(ethylene glycol) methyl ether thiol (Mn 2000)
MERCAPTO POLYETHYLENE GLYCOL 5,000 MONOMETHYL ETHER
O-(2-MERCAPTOETHYL)-O'-METHYLPOLYETHYLENE GLYCOL 5,000
O-(2-Mercaptoethyl)-O'-methylpolyethylene glycol 2,000
O-(2-Mercaptoethyl)-O'-methylpolyethylene glycol 10,000 | [Molecular Formula]
C25H52O12S | [MDL Number]
MFCD00803682 | [MOL File]
134874-49-0.mol | [Molecular Weight]
576.738 |
| Chemical Properties | Back Directory | [form ]
Solid | [color ]
White to off-white | [InChI]
InChI=1S/C25H52O12S/c1-26-2-3-27-4-5-28-6-7-29-8-9-30-10-11-31-12-13-32-14-15-33-16-17-34-18-19-35-20-21-36-22-23-37-24-25-38/h38H,2-25H2,1H3 | [InChIKey]
MXDXXEVQFMVAIA-UHFFFAOYSA-N | [SMILES]
C(COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCS)OC |
| Hazard Information | Back Directory | [Description]
m-PEG12-thiol is a PEG linker containing a thiol group. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
m-PEG-thiol (MW 1000) modifies DNA thiolation for the synthesis of gold nanorods (AuNRs). Thiolated DNA can be loaded onto AuNR by the mPEG-SH/Tween 20 assisted method (Tween 20 and mPEG-SH repeatedly displace CTAB on the AuNR surface). DNA AuNRs have been widely used in nanostructure assembly, gene therapy, biosensing, and drug delivery. | [References]
[1] Li J, et al. Simple and Rapid Functionalization of Gold Nanorods with Oligonucleotides Using an mPEG-SH/Tween 20-Assisted Approach. Langmuir. 2015 Jul 21;31(28):7869-76. DOI:10.1021/acs.langmuir.5b01680 |
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