| Identification | Back Directory | [Name]
1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]piperidinium chloride | [CAS]
135-87-5 | [Synonyms]
933F
piperoxan.HC
piperoxan.HCl
933F Hydrochloride
Benodaine hydrochloride
Piperoxane hydrochloride
Piperoxan (hydrochloride)
Benzodioxane hydrochloride
2-Piperidinomethyl-1,4-benzodioxan hydrochloride
Piperoxan hydrochloride (Benodaine hydrochloride)
2-(1-Piperidylmethyl)-1,4-benzodioxan hydrochloride
1-(1,4-Benzodioxan-2-ylmethyl)piperidine hydrochloride
1,4-Benzodioxan, 2-(1-piperidylmethyl)-, hydrochloride
1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]piperidinium chloride
Piperoxan hydrochloride,Piperoxan,Beta Receptor,Adrenergic Receptor,inhibit,Inhibitor,Benodaine | [EINECS(EC#)]
205-222-3 | [Molecular Formula]
C14H20ClNO2 | [MDL Number]
MFCD00079224 | [MOL File]
135-87-5.mol | [Molecular Weight]
269.767 |
| Chemical Properties | Back Directory | [Melting point ]
229-231 °C | [storage temp. ]
Store at -20°C | [solubility ]
Chloroform: 30 mg/ml; PBS (pH 7.2): 10 mg/ml | [form ]
Solid | [color ]
White to off-white |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302 | [Precautionary statements ]
P264-P270-P301+P312-P330-P501 | [Safety Profile]
Poison by
intraperitoneal and intravenous routes.
Moderately toxic by ingestion and
subcutaneous routes. Experimental
reproductive effects. When heated to
decomposition it emits very toxic fumes of
NO, and HCl. | [Toxicity]
LD50 oral in mouse: 502mg/kg |
| Hazard Information | Back Directory | [Description]
Piperoxan is an α2-adrenergic receptor (α2-AR) antagonist (Kis = 5.4, 2, and 1.3 nM for α2A-, α2B-, and α2C-ARs, respectively) and a first generation histamine receptor antagonist. It reverses decreases in systolic blood pressure induced by clonidine in spontaneously hypertensive rats when administered at a dose of 10 mg/kg. | [Uses]
Piperoxan (Benodaine) hydrochloride is an α2 adrenoceptor antagonist. Piperoxan hydrochloride is the first-generation antihistamine. | [References]
[1] Viemari JC, et al. Nasal trigeminal inputs release the A5 inhibition received by the respiratory rhythm generator of the mouse neonate. J Neurophysiol. 2004 Feb;91(2):746-58. DOI:10.1152/jn.01153.2002
[2] Bentley GA, et al. The antinociceptive action of some beta-adrenoceptor agonists in mice. Br J Pharmacol. 1986 Jul;88(3):515-21. DOI:10.1111/j.1476-5381.1986.tb10231.x |
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