| Identification | Back Directory | [Name]
ZD 8731 | [CAS]
135015-84-8 | [Synonyms]
ZD8731
ZD-8731
ZD 8731
ZD-8731 HCl
ZD-8731 hydrochloride
ZD 8731 HCl,ZD8731 HCl | [Molecular Formula]
C25H22ClN5O | [MOL File]
135015-84-8.mol | [Molecular Weight]
443.94 |
| Hazard Information | Back Directory | [Uses]
ICI-D 8731 (compound 5g) is a angiotensin II receptor antagonist with the IC50 of 0.031 μM. ICI-D 8731 shows a rapid and sustained lowering of blood pressure in a renal hypertensive rat model[1]. | [References]
[1] Bradbury RH, et al. New nonpeptide angiotensin II receptor antagonists. 2. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy)quinoline derivatives. J Med Chem. 1992;35(22):4027-4038. DOI:10.1021/jm00100a007 |
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