| Identification | Back Directory | [Name]
FMOC-ABU-OH | [CAS]
135112-27-5 | [Synonyms]
FMoc-ABu
Fomc-Abu-OH
FMOC-ABU-OH
FMOC-2-ABU-OH
FMOC-L-ABU-OH
FMOC-L-AIB-OH
FMOC-L-2ABU-OH
FMOC-ABU(2)-OH
FMOC-ALPHA-ABU-OH
FMOC-ABU(ALPHA)-OH
Fmoc-2-Abu-OH ,98%
RARECHEM EM WB 0018
FMOC-ABU-OH USP/EP/BP
FMOC-AMINOBUTYRIC ACID
L-Fmoc-Aminobutyric acid
FMOC-L-NHCH(CH2CH3)-COOH
FMOC-2-AMINOBUTANOIC ACID
FMOC-L-2-AMINOBUTYRIC ACID
Fmoc-L-α-aminobutyric acid
FMOC-L-2-AMINOBUTANOIC ACID
FMOC-L-AMINOISOBUTYRIC ACID
L-2-(FMOC-AMINO)BUTYRIC ACID
(S)-FMoc-2-aMinobutyric acid
Fmoc-L-alpha-aminobutyricaci
(S)-Fmoc-2-aminobutanoic Acid
Fmoc-L-α-aminobutyric acid98+%
FMOC-L-ALPHA-AMINOBUTYRIC ACID
(S)-2-(FMoc-aMino)butyric acid, 98%
N-ALPHA-FMOC-L-ALPHA-AMINOBUTYRIC ACID
FMoc-2-Abu-OH(FMoc-2-aMinobutyric acid)
(9H-Fluoren-9-yl)MethOxy]Carbonyl Abu-OH
2-amino-5-(9H-fluoren-9-ylmethoxy)-5-oxopentanoic acid
NALPHA-9-Fluorenylmethoxycarbonyl-L-2-aminobutyric acid
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-2-AMINO-BUTANOIC ACID
N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-2-AMINOBUTYRIC ACID
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-ALPHA-AMINOBUTYRIC ACID
(S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)butanoic acid
(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid
Butanoic acid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (2S)- | [EINECS(EC#)]
828-203-7 | [Molecular Formula]
C19H19NO4 | [MDL Number]
MFCD00080268 | [MOL File]
135112-27-5.mol | [Molecular Weight]
325.36 |
| Chemical Properties | Back Directory | [Melting point ]
161-163°C | [Boiling point ]
550.7±33.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [form ]
solid | [pka]
3.89±0.10(Predicted) | [color ]
White | [Optical Rotation]
[α]20/D 22.0±2°, c = 1% in DMF | [BRN ]
7657232 | [Major Application]
peptide synthesis | [InChI]
1S/C19H19NO4/c1-2-17(18(21)22)20-19(23)24-11-16-14-9-5-3-7-12(14)13-8-4-6-10-15(13)16/h3-10,16-17H,2,11H2,1H3,(H,20,23)(H,21,22)/t17-/m0/s1 | [InChIKey]
XQIRYUNKLVPVRR-KRWDZBQOSA-N | [SMILES]
CC[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
L-Fmoc-Aminobutyric Acid, | [reaction suitability]
reaction type: Fmoc solid-phase peptide synthesis | [Synthesis]
General procedure for the synthesis of Fmoc-L-2-aminobutyric acid from L-2-aminobutyric acid and 9-fluorenylmethyl-N-succinimidyl carbonate: L-2-aminobutyric acid (50.0 g) and sodium bicarbonate (NaHCO3, 81.5 g) were dissolved in water (750 mL) at 20-25 °C. Fmoc-OSu solution [prepared from 171.7 g of 9-fluorenylmethyl-N-succinimidyl carbonate dissolved in 1050 mL of tetrahydrofuran (THF)] was slowly added to the reaction mixture and the reaction was stirred at the same temperature for 5 hours. After completion of the reaction, the reaction mixture was acidified with dilute hydrochloric acid (HCl) to pH < 1.0. The resulting solid was collected by filtration and dried. The crude product was recrystallized from toluene and dried to give Fmoc-L-2-aminobutyric acid. Yield: 135 g; HPLC purity: 99.7%. | [References]
[1] Patent: WO2018/198131, 2018, A1. Location in patent: Page/Page column 11 |
|
|