| Identification | Back Directory | [Name]
PROTAC ER Degrader-2 | [CAS]
1351169-29-3 | [Synonyms]
PROTAC ER Degrader-2
PROTAC ERα Degrader-2
Benzenebutanamide, β-amino-α-hydroxy-N-[(1S)-14-[[(E)-(3-hydroxyestra-1,3,5(10)-trien-17-ylidene)amino]oxy]-1-(2-methylpropyl)-2,13-dioxo-6,9-dioxa-3,12-diazatetradec-1-yl]-, (αS,βR)- | [Molecular Formula]
C42H61N5O8 | [MDL Number]
MFCD32062711 | [MOL File]
1351169-29-3.mol | [Molecular Weight]
763.96 |
| Hazard Information | Back Directory | [Uses]
PROTAC ERα Degrader-2 comprises a IAP ligand binding group, a linker and an estrogen receptor α (ERα) binding group. PROTAC ERα Degrader-2 is an ERα degrader. Maximal ERα degradation at 30 μM concentration in human mammary tumor MCF7 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1]. | [IC 50]
ERα; cIAP1 | [References]
[1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176. DOI:10.1016/j.csbj.2019.01.006 |
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