| Identification | Back Directory | [Name]
(1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)boronic acid | [CAS]
1351413-50-7 | [Synonyms]
(1-methyl-2-oxopyridin-4-yl)boronic acid
(1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)boronic acid
B-(1,2-Dihydro-1-methyl-2-oxo-4-pyridinyl)boronic acid
Boronic acid, B-(1,2-dihydro-1-methyl-2-oxo-4-pyridinyl)- | [Molecular Formula]
C6H8BNO3 | [MDL Number]
MFCD22418629 | [MOL File]
1351413-50-7.mol | [Molecular Weight]
152.94 |
| Chemical Properties | Back Directory | [Boiling point ]
356.2±52.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [pka]
8.26±0.20(Predicted) | [Appearance]
White to yellow Solid |
| Hazard Information | Back Directory | [Uses]
1-Methyl-2-oxo-1,2-dihydro-4-pyridinylboronic Acid is an intermediate used to prepare thiazolopyridine ureas as antitubercular agents acting through inhibition of DNA gyrase B. | [Synthesis]
(3) The residue from step (2) was dissolved in 1,4-dioxane (500-1000 mL), concentrated hydrochloric acid (500-1000 mL) was added slowly at 25°C and the reaction was stirred for 12 hours. Upon completion of the reaction, the organic phase was separated by extraction using ethyl acetate. The aqueous phase product was concentrated under reduced pressure to remove the solvent to give a white solid product (53.3 g, 60% yield). | [References]
[1] Patent: CN106986885, 2017, A. Location in patent: Paragraph 0015; 0016; 0017 |
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