| Identification | Back Directory | [Name]
Benzamide, 4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-[[7-[(phosphonooxy)methyl]-7H-pyrrolo[2,3-b]pyridin-5-yl]oxy]- | [CAS]
1351456-78-4 | [Synonyms]
ABBV-167
Benzamide, 4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-[[7-[(phosphonooxy)methyl]-7H-pyrrolo[2,3-b]pyridin-5-yl]oxy]- | [Molecular Formula]
C46H53ClN7O11PS | [MOL File]
1351456-78-4.mol | [Molecular Weight]
978.45 |
| Chemical Properties | Back Directory | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (102.20 mM; Need ultrasonic) | [form ]
Solid | [pka]
1.50±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
ABBV-167 is a phosphate proagent of the BCL-2 inhibitor venetoclax. | [storage]
Store at -20°C | [References]
[1] Salem AH, et al. Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers. Mol Cancer Ther. 2021 Jun;20(6):999-1008. DOI:10.1158/1535-7163.MCT-21-0077 |
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