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1351941-69-9

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1351941-69-9 Structure

1351941-69-9 Structure

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[Name] 2-Butenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinolinyl]-4-(dimethylamino)-, (2E)-
[CAS] 1351941-69-9
[Synonyms] sacibertinib 2-Butenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinolinyl]-4-(dimethylamino)-, (2E)-
[Molecular Formula] C32H31ClN6O4
[MOL File] 1351941-69-9.mol
[Molecular Weight] 599.08

Chemical Properties	Back Directory
[Boiling point ] 803.7±65.0 °C(Predicted)
[density ] 1.37±0.1 g/cm3(Predicted)
[pka] 12.13±0.43(Predicted)

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[Uses] Sacibertinib is a tyrosine kinase (Trk) inhibitor with EC50 value of 110 nM and 244 nM for EGFR-TK phosphorylation and HER2, respectively. Antineoplastic activity[1].
[IC 50] EGFR-TK phosphorylation: 110 nM (EC₅₀); HER2: 244 nM (EC₅₀)
[References] [1] Hesheng Zhang, et al. Cyanoquinoline derivatives. CA2802130A1 (Example 138) [2] International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 36, No. 2, 2022.

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Company Name:	TargetMol Chemicals Inc.
Telephone:	15002134094
Website:	https://www.targetmol.cn/

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