| Identification | Back Directory | [Name]
AM 8553 | [CAS]
1352064-70-0 | [Synonyms]
AM 8553
YUALYRLIFVPOHL-VPLUBSIMSA-N
3-Piperidineacetic acid, 5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-3-methyl-2-oxo-, (3R,5R,6S)- | [Molecular Formula]
C25H29Cl2NO4 | [MDL Number]
MFCD25976911 | [MOL File]
1352064-70-0.mol | [Molecular Weight]
478.41 |
| Hazard Information | Back Directory | [Description]
AM-8553 is a potent and selective piperidinone inhibitor of the MDM2-p53 interaction. | [Uses]
AM-8553 is a MDM2/p53 inhibitor (KD: 0.4 nM for MDM2). AM-8553 has anti-tumor activity[1] | [References]
[1] Bernard D, et al. AM-8553: a novel MDM2 inhibitor with a promising outlook for potential clinical development. J Med Chem. 2012 Jun 14;55(11):4934-5. DOI:10.1021/jm3007068 |
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