| Identification | Back Directory | [Name]
PF-3450074 | [CAS]
1352879-65-2 | [Synonyms]
PF74
PF 3450074
PF-3450074
PF74 >=98% (HPLC)
2-Methyl-N-[(1S)-2-(methylphenylamino)-2-oxo-1-(phenylmethyl)ethyl]- 1H-indole-3-acetamide
1H-Indole-3-acetamide, 2-methyl-N-[(1S)-2-(methylphenylamino)-2-oxo-1-(phenylmethyl)ethyl]- | [Molecular Formula]
C27H27N3O2 | [MDL Number]
MFCD28160729 | [MOL File]
1352879-65-2.mol | [Molecular Weight]
425.52 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble5mg/mL, clear (warmed) | [form ]
powder | [color ]
white to beige | [InChIKey]
ACDFWSNAQWFRRF-VWLOTQADSA-N | [SMILES]
[nH]1c2c(c(c1C)CC(=O)N[C@@H](Cc4ccccc4)C(=O)N(C)c3ccccc3)cccc2 |
| Hazard Information | Back Directory | [Uses]
PF-3450074 (PF-74) is a specifical inhibitor of HIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC50=8-640 nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle[1][2]. CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153. | [Biological Activity]
PF74 (PF-3450074) is a HIV-1 inhibitor th at targets HIV capsid protein. PF74 binds specifically to HIV-1 particles and triggers premature HIV-1 uncoating in target cells. | [IC 50]
HIV-1 (NL4.3 strain): 0.72 μM (IC50) | [References]
[1] Xu JP, et al. Exploring?Modifications?of an?HIV-1?Capsid?Inhibitor:?Design,?Synthesis, and?Mechanism?of?Action.J Drug Des Res.?2018;5(2). pii: 1070. Epub 2018 Aug 13. PMID:30393786
[2] Shi J, et al. Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization.J Virol. 2011 Jan;85(1):542-9. DOI:10.1128/JVI.01406-10 |
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