| Identification | Back Directory | [Name]
H-ASP-TYR-D-TRP-VAL-D-TRP-D-TRP-LYS-NH2 | [CAS]
135306-85-3 | [Synonyms]
MEN 10376
MEN-10,376 ≥95%
MEN-10,376, ≥95% (HPLC)
MEN-10,376 , ≥95% (HPLC)
M.W. 1081.24 C57H68N12O10
Neurokinin-2 receptor antagonist
ASP-TYR-D-TRP-VAL-D-TRP-D-TRP-LYS-NH2
H-ASP-TYR-D-TRP-VAL-D-TRP-D-TRP-LYS-NH2
tyr(5)-trp(6,8,9)-lys(10)-neurokinina(4-10
[TYR5, D-TRP6,8,9, LYS10]NEUROKININ A (4-10)
L-Asp-L-Tyr-D-Trp-L-Val-D-Trp-D-Trp-L-Lys-NH2
neurokinin A(4-10), Tyr(5)-Trp(6,8,9)-Lys(10)-
(Tyr5,D-Trp6.8.9,Lys-NH21?)-Neurokinin A (4-10)
MEN-10,376 SYNTHETIC >95% NK2 TACHYKININ RECEPT
(tyr5,D-trp6,8,9,lys10)-A-neurokinin*fragment 4-1
(TYR5,D-TRP6,8,9,LYS-NH(2/10))-NEUROKININ A (4-10)
[TYR5,D-TRP6,8 9,LYS10]-ALPHA-NEUROKININ A FRAGMENT 4-10
alpha-neurokinin, fragment 4-10, [Tyr5, Trp6,8,9, Lys10]
(Tyr5,D-Trp6·8·9,Lys-NH210)-Neurokinin A (4-10)
MEN 10376
[TYR5 ,D -TRP6,8 9 ,LYS10 ]-ALPHA-NEUROKININ A FRAGMENT 4-10 97%
L-Lysinamide, L-a-aspartyl-L-tyrosyl-D-tryptophyl-L-valyl-D-tryptophyl-D-tryptophyl-
L-Lysinamide, L-α-aspartyl-L-tyrosyl-D-tryptophyl-L-valyl-D-tryptophyl-D-tryptophyl-
L-alpha-Aspartyl-L-tyrosyl-D-tryptophyl-L-valyl-D-tryptophyl-D-tryptophyl-L-lysinamide
3-amino-4-[[1-[[1-[[1-[[1-[[1-[(1,6-diamino-1-oxohexan-2-yl)amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropa
3-amino-4-[[1-[[1-[[1-[[1-[[1-[(1,6-diamino-1-oxohexan-2-yl)amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-oxobutanoic acid | [Molecular Formula]
C57H68N12O10 | [MDL Number]
MFCD00144736 | [MOL File]
135306-85-3.mol | [Molecular Weight]
1081.22 |
| Chemical Properties | Back Directory | [Boiling point ]
1555.4±65.0 °C(Predicted) | [density ]
1.361±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
solid
| [pka]
3.71±0.10(Predicted) | [color ]
white
| [Sequence]
Asp-Tyr-{d-Trp}-Val-{d-Trp}-{d-Trp}-Lys-NH2 | [InChIKey]
QQHOFZNACVKNHK-UHFFFAOYSA-N | [SMILES]
CC(C)C(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc3ccc(O)cc3)NC(=O)C(N)CC(O)=O)C(=O)NC(Cc4c[nH]c5ccccc45)C(=O)NC(Cc6c[nH]c7ccccc67)C(=O)NC(CCCCN)C(N)=O |
| Hazard Information | Back Directory | [Uses]
MEN10376 is a neurokinin 2 (NK2) receptor antagonist. | [Biochem/physiol Actions]
Potent and selective NK-2 tachykinin receptor antagonist. | [in vivo]
Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats[2]. |
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| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Nextpeptide Inc
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| Telephone: |
+86-0571-81612335 +8613336028439 |
| Website: |
http://www.nextpeptide.com/ |
| Company Name: |
Binhai gill polypeptide co. LTD
|
| Telephone: |
021-61263389 13524856427 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList326362/0_EN.htm |
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