| Identification | Back Directory | [Name]
OBDXBUWPBDVKEB-KSSFIOAISA-N | [CAS]
135383-54-9 | [Synonyms]
OBDXBUWPBDVKEB-KSSFIOAISA-N
(4S,5S)-tert-butyl 4-(((benzyloxy)carbonyl)amino)-5-methyl-3-oxoheptanoate
Heptanoic acid, 5-methyl-3-oxo-4-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, [S-(R*,R*)]- (9CI) | [Molecular Formula]
C20H29NO5 | [MOL File]
135383-54-9.mol | [Molecular Weight]
363.45 |
| Hazard Information | Back Directory | [Uses]
Monomethyl auristatin E intermediate-6 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1]. | [References]
[1] Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87. DOI:10.1158/0008-5472.CAN-14-1931 |
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