| Identification | Back Directory | [Name]
5-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propoxy)benzo[d]thiazole | [CAS]
1354030-52-6 | [Synonyms]
UNC9995
UNC-9995
UNC 9995
5-(3-(4-(2,3-Dichlorophenyl)piperazin-1-yl)propoxy)benzo[d]t...
5-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propoxy)benzo[d]thiazole
Benzothiazole, 5-[3-[4-(2,3-dichlorophenyl)-1-piperazinyl]propoxy]- | [Molecular Formula]
C20H21Cl2N3OS | [MOL File]
1354030-52-6.mol | [Molecular Weight]
422.37 |
| Hazard Information | Back Directory | [Description]
UNC9995 is a β-Arrestin-Biased Dopamine D2 Receptor agonist (β-Arrestin, EC50 = 120 nM; Emax = 88%). | [Uses]
UNC9995 is a β-arrestin2-biased agonist of dopamine receptor Drd2. UNC9995 inhibits NLRP3 inflammasome activation by enhancing β-arrestin2-NLRP3 interaction, thus prevents neuronal degeneration. Futhermore, UNC9995 activates the Drd2/β-arrestin2 signaling to prevent inflammation-related genes transcription-induced by JAK/STAT3. UNC9995 improves depressive behavior in mouse model, and improves astrocytes dysfunctions[1]. | [in vivo]
UNC9995 (2 mg/kg/day, i.p, 2 weeks) ameliorates depressive-like behavioral phenotype and improves the loss of astrocytes in the hippocampus in both Chronic social defeated stress (CSDS) model and Chronic unpredictable mild stress (CUMS) model in mouse[1].
| Animal Model: | Chronic unpredictable mild stress (CUMS) mouse model[1] | | Dosage: | 2 mg/kg/d | | Administration: | IP; 2 weeks | | Result: | Improved depressive-like symptoms of CUMS mouse model in WT mice but not Arrb2?/? mice. |
| [IC 50]
D2 Receptor | [References]
[1] Liu Y, et al. β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression. J Neuroinflammation. 2022 Oct 1;19(1):240. DOI:10.1186/s12974-022-02597-6 |
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