| Identification | Back Directory | [Name]
KH CB19 | [CAS]
1354037-26-5 | [Synonyms]
KH CB19
CS-2131
KH-CB19
(KH-CB-19)
1H-Indole-2-carboxylic acid, 3-[(1E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-, ethyl ester | [Molecular Formula]
C15H13Cl2N3O2 | [MOL File]
1354037-26-5.mol | [Molecular Weight]
338.19 |
| Chemical Properties | Back Directory | [Boiling point ]
604.1±55.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
1.70±0.70(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
KH-CB19 is a potent CLK (cdc2-like kinase) inhibitor (CLK1 IC50=19.7 nM; CLK3 IC50=530 nM). KH-CB19 shows antiviral activity and inhibits influenza virus replication (IC50=13.6?μM)[1][2]. | [IC 50]
CLK1: 19.7 nM (IC50); CLK3: 530 nM (IC50); DYRK1A: 55.2 nM (IC50) | [References]
[1] Fedorov O, et al. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011 Jan 28;18(1):67-76. DOI:10.1016/j.chembiol.2010.11.009
[2] Artarini A, et al. Regulation of influenza A virus mRNA splicing by CLK1. Antiviral Res. 2019 Aug;168:187-196. DOI:10.1016/j.antiviral.2019.06.003 |
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