| Identification | Back Directory | [Name]
Mitochonic acid 5 | [CAS]
1354707-41-7 | [Synonyms]
Mitochonic acid
Mitochonic acid 5
Mitochonic acid 5(MA-5)
α-[2-(2,4-Difluorophenyl)-2-oxoethyl]-1H-indole-3-acetic Acid
1H-Indole-3-acetic acid, α-[2-(2,4-difluorophenyl)-2-oxoethyl]- | [Molecular Formula]
C18H13F2NO3 | [MDL Number]
MFCD31657404 | [MOL File]
1354707-41-7.mol | [Molecular Weight]
329.3 |
| Chemical Properties | Back Directory | [Boiling point ]
573.3±50.0 °C(Predicted) | [density ]
1.426±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:106.66(Max Conc. mg/mL);323.9(Max Conc. mM) | [form ]
A solid | [pka]
4.52±0.37(Predicted) | [color ]
Light yellow to yellow | [InChI]
1S/C18H13F2NO3/c19-10-5-6-12(15(20)7-10)17(22)8-13(18(23)24)14-9-21-16-4-2-1-3-11(14)16/h1-7,9,13,21H,8H2,(H,23,24) | [InChIKey]
BOKQALWNGNLTOC-UHFFFAOYSA-N | [SMILES]
OC(C(CC(C1=C(F)C=C(F)C=C1)=O)C2=CNC3=CC=CC=C32)=O |
| Hazard Information | Back Directory | [Uses]
α-[2-(2,4-Difluorophenyl)-2-oxoethyl]-1H-indole-3-acetic Acid, is a derivative of the plant hormone indole-3-acetic acid, improves survival of fibroblasts from patients with mitochondrial diseases. | [Biological Activity]
Mitochonic Acid 5 is a potent enhancer of mitochondrial ATP production th at significantly increased the cellular ATP level in Hep3B human hepatocellular carcinoma cells. Mitochonic Acid 5 improves the survival of fibroblasts from patients with mitochondrial diseases. It appears th at mitochonic Acid 5 facilitates ATP synthase oligomerization and supercomplex formation with mitofilin/Mic60. | [in vivo]
Administration of Mitochonic acid 5 (MA-5) to an ischemia-reperfusion injury model and a cisplatin-induced nephropathy model improved renal function. To examine the tissue-protective effect of Mitochonic acid 5, the oral bioavailability is examined. Oral administration of Mitochonic acid 5 increases the plasma concentration in a dose-response manner at the peak time of 1 hour[1]. |
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