| Identification | Back Directory | [Name]
6-Chloropurine -9-beta-D-(3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro)arabinoriboside | [CAS]
135473-15-3 | [Synonyms]
9-(3,5-Di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-6-chloropurine
6-Chloropurine-9-β-D-(3’,5’-di-O-benzoyl-2’-deoxy-2’-fluoro)-arabinoriboside
6-Chloro-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-?-D-arabinofuranosyl)-9H-purine
9H-Purine, 6-chloro-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
6-Chloropurine -9-beta-D-(3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro)arabinoriboside
6-Chloro-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purine
((2R,3R,4S,5R)-3-(BENZOYLOXY)-5-(6-CHLORO-9H-PURIN-9-YL)-4-FLUOROTETRAHYDROFURAN-2-YL)METHYL BENZOATE
((2R,3R,4S,5R)-3-(benzoyloxy)-5-(6-chloro-9H-purin-9-yl)-4-fluorotetrahydrofuran-2-yl)methyl benzoate(WXC03256) | [Molecular Formula]
C24H18ClFN4O5 | [MDL Number]
MFCD15145215 | [MOL File]
135473-15-3.mol | [Molecular Weight]
496.87 |
| Chemical Properties | Back Directory | [Boiling point ]
665.6±65.0 °C(Predicted) | [density ]
1.51±0.1 g/cm3(Predicted) | [pka]
0.76±0.10(Predicted) | [InChIKey]
MNHSAXRZPYOLSX-OWJXGRTBNA-N | [SMILES]
C(OC)(=O)C1=CC=CC=C1[C@@H]1[C@@H](OC(=O)C2=CC=CC=C2)[C@H](F)[C@H](N2C3=C(N=C2)C(Cl)=NC=N3)O1 |&1:10,11,21,23,r| |
| Hazard Information | Back Directory | [Uses]
6-Chloro-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. | [References]
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
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