| Identification | Back Directory | [Name]
DC41SMe | [CAS]
1354787-71-5 | [Synonyms]
DC41SMe
1H-Indole-2-carboxamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-5-yl]-5-[[4-methyl-4-(methyldithio)-1-oxopentyl]amino]- | [Molecular Formula]
C38H36ClN5O4S2 | [MDL Number]
MFCD32197185 | [MOL File]
1354787-71-5.mol | [Molecular Weight]
726.31 |
| Hazard Information | Back Directory | [Uses]
DC41SMe, a DC1 derivative, shows cytotoxicity in Ramos, Namalwa, and HL60/s cells with IC50s ranging from 18-25 pM. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer[1][2]. | [IC 50]
Duocarmycins | [References]
[1] Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82. DOI:10.1021/jm201284m
[2] Kovtun YV, et al. Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen. Cancer Res. 2006 Mar 15;66(6):3214-21. DOI:10.1021/jm201284m |
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