| Identification | Back Directory | [Name]
XRLOEZGWBZHADC-UHFFFAOYSA-N | [CAS]
1354955-67-1 | [Synonyms]
GNE-293
GNE-293
(GNE293)
XRLOEZGWBZHADC-UHFFFAOYSA-N
9H-Purine, 9-methyl-2-[2-(1-methylethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-8-[[1-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-3-azetidinyl]oxy]- | [Molecular Formula]
C28H36N8O4S | [MDL Number]
MFCD28411369 | [MOL File]
1354955-67-1.mol | [Molecular Weight]
580.7 |
| Hazard Information | Back Directory | [Description]
GNE-293 is a potent and selective PI3Kδ inhibitor: GNE-293 navigates in vitro genotoxicity while improving potency and selectivity. | [Uses]
GNE-293 is a potent and selective PI3Kδ inhibitor (IC50 = 4.38 nM). GNE-293 has favorable pharmacokinetic properties. GNE-293 can be used for research of asthma, rheumatoid arthritis, and other inflammatory disorders[1]. | [References]
[1] Safina BS, et al. Identification of GNE-293, a potent and selective PI3Kδ inhibitor: navigating in vitro genotoxicity while improving potency and selectivity. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4953-9. DOI:10.1016/j.bmcl.2013.06.052 |
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