| Identification | Back Directory | [Name]
L 697639 | [CAS]
135525-77-8 | [Synonyms]
L 697639
5-Ethyl-6-methyl-3-(4,7-dimethylbenzoxazole-2-ylmethylamino)-2(1H)-pyridinone
5-Ethyl-6-methyl-3-[[(4,7-dimethylbenzoxazol-2-yl)methyl]amino]pyridin-2(1H)-one
3-[(4,7-Dimethylbenzoxazole-2-ylmethyl)amino]-5-ethyl-6-methylpyridine-2(1H)-one
3-[[(4,7-Dimethylbenzoxazol-2-yl)methyl]amino]-5-ethyl-6-methylpyridin-2(1H)-one | [MDL Number]
MFCD00903737 | [MOL File]
135525-77-8.mol |
| Hazard Information | Back Directory | [Uses]
L-697639 is an inhibitor for HIV-1 reverse transcriptase (HIV-1 RT) with IC50 of 20-400 nM (in a template-primer-dependent manner). L-697639 exhibits antiviral activity, that inhibits 95% HIV-1 infection at concentrations of 12-200 nM in human T lymphocyte cultures[1]. | [References]
[1] Goldman ME, et al. Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity. Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6863-7. DOI:10.1073/pnas.88.15.6863 |
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