1356053-63-8

Directory

1356053-63-8 Structure

Identification	Back Directory
[Name] 5-[1-(4-Fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-4-pyrimidinamine
[CAS] 1356053-63-8
[Synonyms] 5-[1-(4-Fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-4-pyrimidinamine
[Molecular Formula] C16H11FN6
[MOL File] 1356053-63-8.mol
[Molecular Weight] 306.3

Chemical Properties	Back Directory
[Boiling point ] 487.3±45.0 °C(Predicted)
[density ] 1.49±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
[pka] 3.76±0.10(Predicted)

Hazard Information	Back Directory
[Uses] BMS-737 (compound 33) is a non-steroidal, reversible small molecule inhibitor. BMS-737 exhibits 11-fold selectivity for CYP17 lyase over CYP17 hydroxylase. BMS-737 is designed to inhibit castration-resistant prostate cancer (CRPC) and significantly reduces testosterone levels without significant effects on orrodermal hormone and glucocorticoid levels[1].
[References] [1] Padmakar Darne C, et al. The discovery of BMS-737 as a potent, CYP17 lyase-selective inhibitor for the treatment of castration-resistant prostate cancer. Bioorg Med Chem Lett. 2022 Nov 1;75:128951. DOI:10.1016/j.bmcl.2022.128951

1356053-63-8 suppliers list

Company Name:	Shanghai Beckham Medical Technology Co., Ltd
Tel:	021-13816613772 13816613772
Website:	www.chemicalbook.com/ShowSupplierProductsList16976/0_EN.htm

Tags:1356053-63-8 Related Product Information

HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.

Login