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1356053-63-8

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1356053-63-8 Structure

1356053-63-8 Structure

Identification	Back Directory
[Name] 5-[1-(4-Fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-4-pyrimidinamine
[CAS] 1356053-63-8
[Synonyms] 5-[1-(4-Fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-4-pyrimidinamine
[Molecular Formula] C16H11FN6
[MOL File] 1356053-63-8.mol
[Molecular Weight] 306.3

Chemical Properties	Back Directory
[Boiling point ] 487.3±45.0 °C(Predicted)
[density ] 1.49±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
[pka] 3.76±0.10(Predicted)

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[Uses] BMS-737 (compound 33) is a non-steroidal, reversible small molecule inhibitor. BMS-737 exhibits 11-fold selectivity for CYP17 lyase over CYP17 hydroxylase. BMS-737 is designed to inhibit castration-resistant prostate cancer (CRPC) and significantly reduces testosterone levels without significant effects on orrodermal hormone and glucocorticoid levels[1].
[References] [1] Padmakar Darne C, et al. The discovery of BMS-737 as a potent, CYP17 lyase-selective inhibitor for the treatment of castration-resistant prostate cancer. Bioorg Med Chem Lett. 2022 Nov 1;75:128951. DOI:10.1016/j.bmcl.2022.128951

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Company Name:	Shanghai Beckham Medical Technology Co., Ltd
Tel:	13816613772
Website:	www.chemicalbook.com/ShowSupplierProductsList16976/0_EN.htm

Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Website:	https://www.targetmol.cn/

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