| Identification | Back Directory | [Name]
3-[[[4-(Hexylamino)-2-methoxyphenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester | [CAS]
1356497-91-0 | [Synonyms]
ST247
ST247 >=98% (HPLC)
3-[[[4-(Hexylamino)-2-methoxyphenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethyleste
3-[[[4-(Hexylamino)-2-methoxyphenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester
2-Thiophenecarboxylic acid, 3-[[[4-(hexylamino)-2-methoxyphenyl]amino]sulfonyl]-, methyl ester | [Molecular Formula]
C19H26N2O5S2 | [MOL File]
1356497-91-0.mol | [Molecular Weight]
426.55 |
| Chemical Properties | Back Directory | [Boiling point ]
595.0±60.0 °C(Predicted) | [density ]
1.285±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble10mg/mL (clear solution) | [form ]
powder | [pka]
8.53±0.50(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
ST247 a potent PPARβ/δ inverse agonist. ST247 has a higher affinity to PPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity of PPARβ/δ[1]. | [Biological Activity]
ST247 is a PPAR β/δ selective inverse agonist. The compound is based on the structure of GSK0660and is 10-fold more potent in blocking the transcription of endogenous target genes: ST247 IC50 = 19 nm vs. GSK0660 IC50 = 210 nM. | [IC 50]
PPARβ/δ | [References]
[1] Naruhn S, et al. High-affinity peroxisome proliferator-activated receptor β/δ-specific ligands with pure antagonistic or inverse agonistic properties. Mol Pharmacol. 2011 Nov;80(5):828-38. DOI:10.1124/mol.111.074039 |
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