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135662-06-5

135662-06-5 Structure

135662-06-5 Structure
IdentificationBack Directory
[Name]

Dnp-PYAYWMR (trifluoroacetate salt)
[CAS]

135662-06-5
[Synonyms]

Dnp-pyaywmr trifluoroacetate
Dnp-PYAYWMR (trifluoroacetate salt)
L-Arginine, 1-(2,4-dinitrophenyl)-L-prolyl-L-tyrosyl-L-alanyl-L-tyrosyl-L-tryptophyl-L-methionyl-
1-(2,4-dinitrophenyl)-L-prolyl-L-tyrosyl-L-alanyl-L-tyrosyl-L-tryptophyl-L-methionyl-L-arginine,trifluoroacetatesalt
[Molecular Formula]

C54H65N13O14S
[MOL File]

135662-06-5.mol
[Molecular Weight]

1152.24
Chemical PropertiesBack Directory
[density ]

1.50±0.1 g/cm3(Predicted)
[solubility ]

Formic Acid: 1 mg/ml
[pka]

3.29±0.10(Predicted)
[Sequence]

{DNP}-Pro-Tyr-Ala-Tyr-Trp-Met-Arg
Hazard InformationBack Directory
[Uses]

Dnp-PYAYWMR is a peptide substrate that selectively targets MMP3. Dnp-PYAYWMR is cleaved by MMP3 to produce Dnp-PYA (nonfluorescent) and YWMR (fluorophore detectable at 360 nm). After incubation of MMP3 with Dnp-PYAYWMR for 2 h, MMP3 fluorescence intensity was measured. Ex/Em=328/350 nm[1].
[References]

[1] Li Y, et al. Combination of serum matrix metalloproteinase-3 activity and EBV antibodies improves the diagnostic performance of nasopharyngeal carcinoma. J Cancer. 2020 Aug 18;11(20):6009-6018. DOI:10.7150/jca.46977
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