| Identification | Back Directory | [Name]
N-BOC-4-ETHYL PIPERIDINECARBOXYLATE | [CAS]
135716-09-5 | [Synonyms]
Ethyl 1-Boc-4-piperidine ...
Ethyl N-Boc-4-piperidineacetate
Ethyl 1-Boc-4-piperidine acetate
N-BOC-4-ETHYL PIPERIDINECARBOXYLATE
1-[(tert-butoxy)carbonyl]-4-ethylpiperidine-2-carboxylate
tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidin-1-carboxylate
2-(1-tert-Butoxycarbonyl-4-piperidyl)acetic acid ethyl ester
4-(2-ethoxy-2-oxoethyl)-1-piperidinecarboxylic acid tert-butyl ester
((Ethoxycarbonyl)methyl)piperidine-1-carboxylic acid tert-butyl ester
4-(2-ethoxy-2-keto-ethyl)piperidine-1-carboxylic acid tert-butyl ester
4-Piperidineacetic acid, 1-[(1,1-diMethylethoxy)carbonyl]-, ethyl ester
tert-butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate(SALTDATA: FREE) | [Molecular Formula]
C14H25NO4 | [MDL Number]
MFCD08458317 | [MOL File]
135716-09-5.mol | [Molecular Weight]
271.35 |
| Chemical Properties | Back Directory | [Melting point ]
19.68° C (Predicted) | [Boiling point ]
339.2±15.0 °C(Predicted) | [density ]
1.048±0.06 g/cm3(Predicted) | [refractive index ]
n20D 1.47 (Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
solid | [pka]
-1?+-.0.40(Predicted) | [Appearance]
Colorless to light yellow Liquid | [InChI]
1S/C14H25NO4/c1-5-18-12(16)10-11-6-8-15(9-7-11)13(17)19-14(2,3)4/h11H,5-10H2,1-4H3 | [InChIKey]
PQEXLIRUMIRSAL-UHFFFAOYSA-N | [SMILES]
CCOC(=O)CC1CCN(CC1)C(=O)OC(C)(C)C |
| Hazard Information | Back Directory | [Uses]
tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate is used as a building block for the synthesis of organic compounds and drugs.
| [Synthesis]
Tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate (22 g, 81.8 mmol) was added to wet 10% Pd/C (2.2 g) and ethanol (160 mL), and the mixture was degassed and backfilled three times with hydrogen. The reaction mixture was stirred at room temperature for 2 h under the protection of a hydrogen balloon. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford tert-butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate (22.5 g, 100% yield). The m/z (M-100) was 172.1 as detected by LRMS, which was consistent with the theoretical value of 172.1. | [References]
[1] Heterocycles, 2001, vol. 54, # 2, p. 747 - 755
[2] Patent: WO2018/68297, 2018, A1. Location in patent: Page/Page column 135; 136
[3] Patent: WO2018/152329, 2018, A1. Location in patent: Page/Page column 48
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995, # 6, p. 641 - 644
[5] Chinese Chemical Letters, 2012, vol. 23, # 6, p. 707 - 710 |
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