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KUS121, a valosin-containing protein (VCP, p97) modulator with significant neuroprotective effects, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress[1][2]. | [in vivo]
KUS121 (IVT injection, 25 μg/eye) appears to show a better suppression of inner retinal thinning 7 and 14 days after the ischemic insult. KUS121 (IVT injection) also shows a better preservation of GFP-positive RGCs and equally preserved b-wave amplitude 14 days after the insult. KUS121 (IVT injection) also exerts neuroprotective effects on retinal morphology and function after ischemic damage[1].
KUS121 suppresses thinning of the outer nuclear layer and maintained visual function. KUS121 (retinas) suppresses endoplasmic reticulum stress, activates mammalian target of rapamycin and suppresses disease-associated apoptosis[3]. | [References]
[1] KUS121, a VCP modulator, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress. Sci Rep. 2017 Mar 20:7:44873. DOI:10.1038/srep44873
[2] Hisanori Kinoshita, et al. KUS121, a valosin-containing protein modulator, attenuates ischemic stroke via preventing ATP depletion. Sci Rep. 2019 Aug 8;9(1):11519. DOI:10.1038/s41598-019-47993-w
[3] Tomoko Hasegawa, et al. Neuoroprotective efficacies by KUS121, a VCP modulator, on animal models of retinal degeneration. Sci Rep. 2016 Aug 9:6:31184. DOI:10.1038/srep31184 |
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