| Identification | Back Directory | [Name]
S 14671 | [CAS]
135722-27-9 | [Synonyms]
S 14671
N-[2-[4-(7-Methoxynaphthalen-1-yl)piperazin-1-yl]ethyl]-2-thiophenecarboxamide
N-[2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl]thiophene-2-carboxamide
2-Thiophenecarboxamide, N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]- | [Molecular Formula]
C22H25N3O2S | [MDL Number]
MFCD00905005 | [MOL File]
135722-27-9.mol | [Molecular Weight]
395.52 |
| Hazard Information | Back Directory | [Description]
S-14671 is a 5-HT1A receptor agonist (pKi = 9.3) with high efficacy and exceptional in vivo potency, and also as a 5-HT2A and 5-HT2C receptor antagonist (both are pKi = 7.8). It displays only low and non-significant affinity for 5-HT1B and 5-HT3 sites. | [Uses]
S-14671 is a high-affinity 5-HT1A agonist (pKi=9.3). S-14671 can be used for research on neurological diseases, such as anti-anxiety, anti-depression, etc[1]. | [IC 50]
5-HT1A Receptor: 9.3 (pKi) | [References]
[1] Millan MJ, et al. S 14671: a novel naphthylpiperazine 5-HT1A agonist of high efficacy and exceptional in vivo potency. Eur J Pharmacol. 1991 Oct 15;203(2):319-22. DOI:10.1016/0014-2999(91)90734-8 |
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