ChemicalBook--->CAS DataBase List--->135729-56-5

135729-56-5

Request For Quotation
135729-56-5 Structure

135729-56-5 Structure
IdentificationBack Directory
[Name]

Palonosetron
[CAS]

135729-56-5
[Synonyms]

Palonosteron
RS 25233-198
PALMATINE(P)
Unii-5D06587D6r
(S)-2-(1-Azabicyclo[2.2.2]oct-3-yl)-2,4,5,6-tetrahydro-1H-benz[de]isoquinolin-1-one
1H-Benz[de]isoquinolin-1-one, 2-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,4,5,6-tetrahydro-
(3AS)-2-(S)-1-AZABICYCLO[2,2,2]OCT-3-YL)-2,3,3A,4,5,6-HEXAHYDRO-1H-BENZ(D)ISOQUINOLIN-1-ONE
(3AS)-2-[(3S)-1-AZABICYCLO[2.2.2]OCT-3-YL]-2,3,3A,4,5,6-HEXAHYDRO-1H-BENZ[DE]ISOQUINOLIN-1-ONE
Palonosetron (3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one
[Molecular Formula]

C19H22N2O
[MDL Number]

MFCD07783848
[MOL File]

135729-56-5.mol
[Molecular Weight]

294.39
Chemical PropertiesBack Directory
[Boiling point ]

511.0±50.0 °C(Predicted)
[density ]

1.24
[pka]

9.77±0.33(Predicted)
Hazard InformationBack Directory
[Uses]

Palonosetron can be used to Anti-emetic; antinauseant.
[Brand name]

Aloxi (Helsinn).
[in vivo]

In anesthetized rats, Dehydro Palonosetron (RS 42358-197), administered by the intravenous, intraduodenal or transdermal route, dose-dependently inhibited the Bezold-Jarisch reflex induced by 2-methyl 5-HT (ID50:0.05 μg/kg; i.v., 5.7 μg/kg; i.d., and 11.6 μg/chamber, respectively)[1].
Dehydro Palonosetron (RS 42358-197; 0.01 ng/kg-10 mg/kg; oral administration; once) disinhibits behaviour in the mouse suppressed by the aversive situation of the light/dark test box[2].

Animal Model:Male albino BKW mice (30-35 g)[2]
Dosage:0.01 ng/kg, 0.1 ng/kg, 1 ng/kg, 100 ng/kg, 1 μg/kg, 100 μg/kg, 1 mg/kg, 10 mg/kg
Administration: Oral administration; once
Result:Increased the proportion of time mice spent and the number of rearings and line crossings in the light area of the test chamber.
[IC 50]

5-HT3 Receptor
135729-56-5 suppliers list
Company Name: Daicel Chiral Technologies (China)CO.,LTD  
Telephone: 021-50460086-9 15921403865
Website: http://www.daicelchiraltech.cn/reagents/Default.aspx
Company Name: Shanghai Holy Biohemdeviser Co., Ltd  
Telephone: 021-61551100
Website: www.chemicalbook.com/ShowSupplierProductsList15343/0_EN.htm
Company Name: Chengdu DingDang Pharmaceutical Co., Ltd.  
Telephone: 028-86040038
Website: http://www.dingdangchem.com
Company Name: Roark Standards  
Telephone: 0755-83552066 15986688328
Website: roarkstandards.com
Company Name: Amatek Scientific Co. Ltd.  
Telephone: 0512-56316828 400-867-5858;400-867-5858
Website: http://www.amateksci.com
Company Name: Jinan Yaoyan Pharmaceutical Co., Ltd.  
Telephone:
Website: www.chemicalbook.com/ShowSupplierProductsList30574/0_EN.htm
Company Name: Henan Alfachem Co.,Ltd.  
Telephone: 0371-55051623 18137891487
Website: www.chemicalbook.com/supplier/14555231/
Company Name: Alchemist-pharm chemical Technology Co. Ltd.  
Telephone: 0371-67991738 13783628208
Website: www.alchemist-pharm.com
Company Name: Shenzhen Botel Biotechnology Co. Ltd.  
Telephone: 13316949107 13316968096
Website: http://www.szbotaier.com/
Company Name: TOSUN PHARM  
Telephone: 020-66392521-118 18922260391
Website: www.toref.cn/
Company Name: Nanjing Meihao Pharmaceutical Technology Co., Ltd.  
Telephone: meitaochem@126.com
Website: www.chemicalbook.com/ShowSupplierProductsList31244/0_EN.htm
Company Name: CONIER CHEM AND PHARMA LIMITED  
Telephone:
Website: http://www.conier.com/
Company Name: Nanjing wangzhixing Pharmaceutical Technology Co., Ltd  
Telephone: 18569809817
Website: www.wzxchem.com
Company Name: career henan chemical co  
Telephone: +86-0371-86658258
Website: www.coreychem.com
Company Name: Wuxi Helen Biotechnology Co., Ltd.,  
Telephone: 0510-85629785 18013409632
Website: http://www.reading-chemicals.com
Company Name: Guangzhou Juntang Technology Co., Ltd  
Telephone: 020-36607679 13502246435
Website: www.dmstandards.com
Company Name: Beijing Fuchen Technology Co., Ltd  
Telephone: 15652759959
Website: www.chemicalbook.com/ShowSupplierProductsList914906/0_EN.htm
Company Name: Scinova Biotech(Guangzhou) Co., Ltd.  
Telephone: 13268215580
Website: www.scinova-e.com/
Tags:135729-56-5 Related Product Information
89565-68-4 3486-67-7 135729-62-3