| Identification | Back Directory | [Name]
Palonosetron | [CAS]
135729-56-5 | [Synonyms]
Palonosteron
RS 25233-198
PALMATINE(P)
Unii-5D06587D6r
(S)-2-(1-Azabicyclo[2.2.2]oct-3-yl)-2,4,5,6-tetrahydro-1H-benz[de]isoquinolin-1-one
1H-Benz[de]isoquinolin-1-one, 2-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,4,5,6-tetrahydro-
(3AS)-2-(S)-1-AZABICYCLO[2,2,2]OCT-3-YL)-2,3,3A,4,5,6-HEXAHYDRO-1H-BENZ(D)ISOQUINOLIN-1-ONE
(3AS)-2-[(3S)-1-AZABICYCLO[2.2.2]OCT-3-YL]-2,3,3A,4,5,6-HEXAHYDRO-1H-BENZ[DE]ISOQUINOLIN-1-ONE
Palonosetron (3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one | [Molecular Formula]
C19H22N2O | [MDL Number]
MFCD07783848 | [MOL File]
135729-56-5.mol | [Molecular Weight]
294.39 |
| Hazard Information | Back Directory | [Uses]
Palonosetron can be used to Anti-emetic; antinauseant.
| [Brand name]
Aloxi (Helsinn). | [in vivo]
In anesthetized rats, Dehydro Palonosetron (RS 42358-197), administered by the intravenous, intraduodenal or transdermal route, dose-dependently inhibited the Bezold-Jarisch reflex induced by 2-methyl 5-HT (ID50:0.05 μg/kg; i.v., 5.7 μg/kg; i.d., and 11.6 μg/chamber, respectively)[1].
Dehydro Palonosetron (RS 42358-197; 0.01 ng/kg-10 mg/kg; oral administration; once) disinhibits behaviour in the mouse suppressed by the aversive situation of the light/dark test box[2]. | Animal Model: | Male albino BKW mice (30-35 g)[2] | | Dosage: | 0.01 ng/kg, 0.1 ng/kg, 1 ng/kg, 100 ng/kg, 1 μg/kg, 100 μg/kg, 1 mg/kg, 10 mg/kg | | Administration: |
Oral administration; once | | Result: | Increased the proportion of time mice spent and the number of rearings and line crossings in the light area of the test chamber. |
| [IC 50]
5-HT3 Receptor |
|
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