| Identification | Back Directory | [Name]
1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | [CAS]
1357349-91-7 | [Synonyms]
SPP 86
SPP86 >=98% (HPLC)
1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1-methylethyl)-3-(2-phenylethynyl)- | [Molecular Formula]
C16H15N5 | [MOL File]
1357349-91-7.mol | [Molecular Weight]
277.32 |
| Chemical Properties | Back Directory | [Boiling point ]
495.3±40.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
3.95±0.30(Predicted) | [color ]
Off-white to light yellow | [InChI]
1S/C16H15N5/c1-11(2)21-16-14(15(17)18-10-19-16)13(20-21)9-8-12-6-4-3-5-7-12/h3-7,10-11H,1-2H3,(H2,17,18,19) | [InChIKey]
JQOIRTDBHMDWMT-UHFFFAOYSA-N | [SMILES]
NC1=NC=NC2=C1C(C#CC3=CC=CC=C3)=NN2C(C)C |
| Hazard Information | Back Directory | [Uses]
SPP 86 is a potent RET Kinase inhibitor. | [Biological Activity]
SPP86 is a potent cell permeable inihbitor of RET tyrosine kinase with an IC50 value of 8 nM and with some inhibitory activity at EphA1FGFR1Flt4Lck and Yes. SPP86 does not inhibit p38CSKKITPDGFSrc or BCR-ABL. SPP86 inhibited RET-mediated activation of the PI3K/Akt and MAPK pathways at doses of 0.1- 1 μM in a cell line expressing oncogenic RET and inhibited RET-induced ERα phosphorylation and proliferation in MCF7 cells with an IC50 value of 1.0 μMsimilar to tamoxifen. | [storage]
Store at +4°C |
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BOC Sciences
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