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1357350-60-7

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1357350-60-7 Structure

1357350-60-7 Structure
IdentificationBack Directory
[Name]

ALLO-2 (Smo inhibitor ALLO-2)
[CAS]

1357350-60-7
[Synonyms]

ALLO-2
ALLO-2 (Smo inhibitor ALLO-2)
1H-Indazol-5-amine, N-[4-[4-(trifluoromethoxy)phenyl]-2-pyrimidinyl]-
[Molecular Formula]

C18H12F3N5O
[MOL File]

1357350-60-7.mol
[Molecular Weight]

371.32
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 125 mg/mL (336.64 mM)
[form ]

Solid
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM[1].
[References]

[1] Tao H, et al. Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. Chem Biol. 2011 Apr 22;18(4):432-7. DOI:10.1016/j.chembiol.2011.01.018
Spectrum DetailBack Directory
[Spectrum Detail]

ALLO-2 (Smo inhibitor ALLO-2)(1357350-60-7)1HNMR
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