| Identification | Back Directory | [Name]
2-Naphthalenecarboxylic acid, 6-(4-methylpentyl)- | [CAS]
1357838-47-1 | [Synonyms]
UBP684
UBP-684
UBP 684
2-Naphthalenecarboxylic acid, 6-(4-methylpentyl)- | [Molecular Formula]
C17H20O2 | [MOL File]
1357838-47-1.mol | [Molecular Weight]
256.34 |
| Hazard Information | Back Directory | [Description]
UBP684 is a NMDAR pan-PAM (positive allosteric modulator) which robustly potentiates responses at all GluN1/GluN2 subtypes and at neuronal NMDARs. UBP684 increases the maximal l-glutamate/glycine response while having minor subunit-specific effects on agonist potency. | [Uses]
UBP684 is a novel positive allosteric modulator of NMDA receptors (NMDARs) that enhances receptor function by stabilizing the ligand-binding domains in a closed conformation, resulting in potentiated whole-cell currents and increased mean open time. | [References]
[1] A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors DOI:10.1038/s41598-017-07292-8 |
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