| Identification | Back Directory | [Name]
N-(3-Chloro-4-fluorophenyl)-1-[2-(3-methylphenyl)-4-pyrimidinyl]-4-piperidinecarboxamide | [CAS]
1358617-36-3 | [Synonyms]
BC-1901S
N-(3-Chloro-4-fluorophenyl)-1-[2-(3-methylphenyl)-4-pyrimidinyl]-4-piperidinecarboxamide | [Molecular Formula]
C23H22ClFN4O | [MOL File]
1358617-36-3.mol | [Molecular Weight]
424.9 |
| Chemical Properties | Back Directory | [Boiling point ]
571.0±50.0 °C(Predicted) | [density ]
1.309±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
12.89±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
BC-1901S is a proteasome-independent NRF2 activator and stabilizer. BC-1901S binds to DCAF1 (E3 ligase subunit) and disrupts NRF2/DCAF1 interaction, and activates NRF2 by inhibiting NRF2 ubiquitination in a KEAP1-independent manner. BC-1901S shows anti-inflammatory effect in a murine model of LPS-induced acute lung injury[1]. | [References]
[1] Chen Y, et al. A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis. Redox Biol. 2020 May;32:101485. DOI:10.1016/j.redox.2020.101485 |
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