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A 65282 is an antibacterial isothiazoloquinolone. It induces considerable DNA breakage mediated by calf thymus topoisomerase II. A 65282 is a potent inhibitor of the P4-unknotting reaction. | [Uses]
A-65282 is an antibacterial agent. A-65282 inhibits P4 DNA unknotting with an IC50 value of 8 μg/mL. A 65281 induces DNA breakage mediated by calf thymus topoisomerase II[1]. | [References]
[1] Kohlbrenner WE, et al. Induction of calf thymus topoisomerase II-mediated DNA breakage by the antibacterial isothiazoloquinolones A-65281 and A-65282. Antimicrob Agents Chemother. 1992 Jan;36(1):81-6. DOI:10.1128/AAC.36.1.81 |
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