| Identification | Back Directory | [Name]
AVL 292 benzenesulfonate | [CAS]
1360053-81-1 | [Synonyms]
AVL-292 besylate
CC-292 besylate)
Spebrutinib besylate
AVL292 benzenesulfonate
AVL 292 benzenesulfonate
AVL-292 (benzenesulfonate)
SPEBRUTINIB BESYLATE;CC-292 BESYLATE
Spebrutinib (AVL-292) benzenesulfonate
Spebrutinib besylate (AVL-292 benzenesulfonate
SPEBRUTINIB BESYLATE (AVL-292 BENZENESULFONATE; CC-292 BESYLATE)
AVL292 BENZENESULFONATE; AVL 292 BENZENESULFONATE; SPEBRUTINIB BESYLATE; CC-292 BESYLATE | [Molecular Formula]
C28H28FN5O6S | [MDL Number]
MFCD26142937 | [MOL File]
1360053-81-1.mol | [Molecular Weight]
581.62 |
| Hazard Information | Back Directory | [Uses]
Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a potent inhibitor of Btk kinase activity (IC50<0.5 nM, Kinact/Ki=7.69×104 M-1s-1s) in biochemical assays. | [storage]
Store at -20°C | [References]
[1] Evans EK, et al. Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans. J Pharmacol Exp Ther. 2013 Aug;346(2):219-28. DOI:10.1124/jpet.113.203489 |
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