| Identification | Back Directory | [Name]
methyl 6-methylpyridine-2-carboxylate | [CAS]
13602-11-4 | [Synonyms]
NSC 109151
Methyl 6-methylpicolinate
6-Methylpicolinic Acid Methyl Ester
Methyl 6-methyl-2-pyridinecarboxylate
methyl 6-methylpyridine-2-carboxylate
METHYL-6-MENTHYPYRIDINE-2-CARBOXYLATE
Methyl6-Methylpyridine-2-carboxylate>
Methyl6-methylpyridine-2-carboxylate,96%
6-Methyl-2-pyridinecarboxylic acid methyl ester
Methyl 6-methylpyridine-2-carboxylate(13602-11-4)
2-Pyridinecarboxylic acid, 6-Methyl-, Methyl ester
2-Pyridinecarboxylicacid,6-methyl-,methylester(9CI)
methyl 6-methylpyridine-2-carboxylate ISO 9001：2015 REACH | [EINECS(EC#)]
237-085-0 | [Molecular Formula]
C8H9NO2 | [MDL Number]
MFCD06203670 | [MOL File]
13602-11-4.mol | [Molecular Weight]
151.163 |
| Chemical Properties | Back Directory | [Melting point ]
18 °C | [Boiling point ]
242℃ | [density ]
1.104 | [refractive index ]
1.5160-1.5200 | [Fp ]
100℃ | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
powder to lump to clear liquid | [pka]
1.93±0.10(Predicted) | [color ]
White or Colorless to Light yellow |
| Hazard Information | Back Directory | [Uses]
Methyl 6-Methylpyridine-2-carboxylate is a reagent used in the sunthesis of antitumor agents based upon the dihydropyrrolopyrazole compounds. Also used in the synthesis of quinazolinone TGF-β inhibitors. | [Synthesis]
Step 2: 26.8 g (0.195 mol) of SOCl2 was slowly added dropwise to 100 mL of methanol at a low temperature of -10 °C while stirring was continued. After the dropwise addition, the reaction mixture was gradually warmed up to room temperature and stirring was continued for 1 hour. Subsequently, 10 g of 6-methyl-2-pyridinecarboxylic acid (Compound 2) was added to the reaction system and the reaction was refluxed at 80 °C for 5 hours. Upon completion of the reaction, 10.2 g of methyl 6-methyl-2-pyridinecarboxylate (Compound 3) was obtained in 93% yield. | [References]
[1] Patent: CN105294552, 2016, A. Location in patent: Paragraph 0047; 0051
[2] Patent: WO2004/48383, 2004, A1. Location in patent: Page 40
[3] Patent: WO2004/48382, 2004, A1. Location in patent: Page 8
[4] Patent: WO2016/187308, 2016, A1. Location in patent: Paragraph 0349
[5] Patent: WO2012/80221, 2012, A1. Location in patent: Page/Page column 98 |
|
|