| Identification | Back Directory | [Name]
Vaborbactam | [CAS]
1360457-46-0 | [Synonyms]
CS-2636
RPX7009
Vaborbactam
{(3R,6S)-2-Hydroxy-3-[(2-thienylacetyl)amino]-1,2-oxaborinan-6-yl}acetic acid
1,2-Oxaborinane-6-acetic acid, 2-hydroxy-3-[[2-(2-thienyl)acetyl]amino]-, (3R,6S)-
2-((3R,6S)-2-HYDROXY-3-(2-(THIOPHEN-2-YL)ACETAMIDO)-1,2 OXABORINAN-6-YL)ACETIC ACID | [Molecular Formula]
C12H16BNO5S | [MDL Number]
MFCD28502176 | [MOL File]
1360457-46-0.mol | [Molecular Weight]
297.14 |
| Chemical Properties | Back Directory | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer, Under inert atmosphere | [solubility ]
Methanol (Slightly) | [form ]
Solid | [pka]
4.28±0.10(Predicted) | [color ]
Pale Brown to Light Brown |
| Hazard Information | Back Directory | [Uses]
Vaborbactam is a non-β-lactam β-lactamase inhibitor. While not effective as an antibiotic by itself, it restores potency to existing antibiotics by inhibiting the beta-lactamase enzymes that would otherwise degrade them. When combined with an appropriate antibiotic it can be used for the treatment of gram-negative bacterial. | [in vivo]
Vaborbactam is well tolerated and has a half-life of 1.23 h, and steadystate volume of distribution of 21.0 L in subjects[3]. |
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