| Identification | Back Directory | [Name]
Tetradeca-4,12-diene-8,10-diyne-1,6,7-triol | [CAS]
136171-87-4 | [Synonyms]
Lobetyol
4,12-Tetradecadiene-8,10-diyne-1,6,7-triol
Tetradeca-4,12-diene-8,10-diyne-1,6,7-triol | [Molecular Formula]
C14H18O3 | [MDL Number]
MFCD21333772 | [MOL File]
136171-87-4.mol | [Molecular Weight]
234.29 |
| Hazard Information | Back Directory | [Uses]
Lobetyol is a natural compound that can be isolated from Lobelia chinensis. Lobetyol induces apoptosis and cell cycle arrest in MKN45 cells. Lobetyol shows anti-virus, anti-inflammation and anti-tumor activity[1][2]. Lobetyol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [in vivo]
Lobetyol (0-10 mg/kg, Once per 3 days) suppresses tumor growth in MKN45 nude models[1]. | Animal Model: | BALB/C nude mice (6 weeks-old, injected intraperitoneally with MKN45 cells)[1] | | Dosage: | 0, 2, 5, 10 mg/kg | | Administration: | Once per 3 days | | Result: | Suppressed tumor growth in MKN45 nude models. The protein levels of Ki67 in MKN45 cells were significantly decreased. Meanwhile, cleaved-caspase-3 positive MKN45 cells were found increased with the tendency of lobetyol concentrations in the study in vivo. |
| [IC 50]
Bax; Bcl-2 | [References]
[1] Shen J, et al. Lobetyol activate MAPK pathways associated with G1/S cell cycle arrest and apoptosis in MKN45 cells in vitro and in vivo. Biomed Pharmacother. 2016 Jul;81:120-127. DOI:10.1016/j.biopha.2016.03.046
[2] Xie Q, et al. The in vitro/in vivo metabolic pathways analysis of lobetyol, lobetyolin, and lobetyolinin, three polyacetylenes from Codonopsis Radix, by UHPLC-Q/TOF-MS and UHPLC-MS/MS. J Pharm Biomed Anal. 2023 Jan 20;223:115140. DOI:10.1016/j.jpba.2022.115140 |
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