| Identification | Back Directory | [Name]
DERMASEPTIN PHYLLOMEDUSA SAUVAGII | [CAS]
136212-91-4 | [Synonyms]
Attacin
PubChem ID: 16130489
Antibacterial peptide
Dermaseptin Lyophilized
HPRP-A1 Ac-FKKLKKLFSKLWNWK-NH2
DERMASEPTIN PHYLLOMEDUSA SAUVAGII
dermaseptin from phyllomedusa sauvagii
Dermaseptin from phyllomedusa sauvagii, ≥97% (HPLC)
ala-leu-trp-lys-thr-met-leu-lys-lys-leu-gly-thr-met-ala-leu-his-ala-gly-lys-ala-ala-leu-gly-ala-ala-ala-asp-thr-ile-ser-gln-gly-thr-gln | [Molecular Formula]
C152H257N43O44S2 | [MDL Number]
MFCD00146655 | [Molecular Weight]
3455.06 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [solubility ]
Soluble in DMSO | [form ]
Lyophilized powder | [color ]
White to off-white | [Sequence]
H-Ala-Leu-Trp-Lys-Thr-Met-Leu-Lys-Lys-Leu-Gly-Thr-Met-Ala-Leu-His-Ala-Gly-Lys-Ala-Ala-Leu-Gly-Ala-Ala-Ala-Asp-Thr-Ile-Ser-Gln-Gly-Thr-Gln-OH |
| Hazard Information | Back Directory | [Uses]
Dermaseptin, a peptide isolated from frog skin, exhibits potent antimicrobial activity against?bacteria,?fungi, and protozoa?at micromolar concentration[1]. | [Biological Activity]
Dermaseptin is a polypeptide isolated from frog skin that exhibits potent antimicrobial activity against bacteria, fungi and protozoa. | [in vitro]
Dermaseptin is a water-soluble, thermostable, and nonhemolytic peptide endowed with highly potent antimicrobial activity against pathogenic fungi at micromolar concentration. | [Source]
Dermaseptin is derived from insect antimicrobial peptides; mammalian antimicrobial peptides; amphibian antimicrobial peptides; fish, mollusk and crustacean derived antimicrobial peptides; plant antimicrobial peptides and bacterial antimicrobial peptides. | [storage]
Store at -20°C | [References]
[1] Mor A, et al. Isolation, amino acid sequence, and synthesis of dermaseptin, a novel antimicrobial peptide of amphibian skin. Biochemistry. 1991 Sep 10;30(36):8824-30. DOI:10.1021/bi00100a014
[2] Mor A, et al. The NH2-terminal alpha-helical domain 1-18 of dermaseptin is responsible for antimicrobial activity. J Biol Chem. 1994 Jan 21;269(3):1934-9. PMID:8294443 |
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