| Identification | Back Directory | [Name]
(3N-[(2S,3S)-2-AMINO-3-METHYL-PENTANOYL]-1,3-THIAZOLIDINE) HEMIFUMARATE | [CAS]
136259-20-6 | [Synonyms]
P32/98
1-Pentanone, 2-amino-3-methyl-1-(3-thiazolidinyl)-, (2S,3S)-
(3N-[(2S,3S)-2-AMINO-3-METHYL-PENTANOYL]-1,3-THIAZOLIDINE) HEMIFUMARATE | [Molecular Formula]
C9H18N2OS | [MDL Number]
MFCD06798386 | [MOL File]
136259-20-6.mol | [Molecular Weight]
202.32 |
| Chemical Properties | Back Directory | [Boiling point ]
351.8±37.0 °C(Predicted) | [density ]
1.118±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (up to 25 mg/ml) or in Water (up to 20 mg/ml). | [form ]
White solid. | [pka]
8.53±0.39(Predicted) | [color ]
White | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month. |
| Hazard Information | Back Directory | [Description]
P32/98 (136259-20-6) is a potent and selective inhibitor of dipeptidyl peptidase IV (DPPIV) (Ki=130 nM). May be used in cell cuture (1-10 μM) or in vivo (10 mg/kg orally). Cell permeable. Experimental anti-diabetic agent. This product not approved for human therapeutic use. | [Uses]
P32/98 is a dipeptidyl peptidase IV inhibitor which is used in hypertensive patients treated with antihpertensive drugs. | [in vivo]
P32/98 (25 mg/kg; i.g.; once daily) long-time treatment significantly improves the glucose tolerance in Zucker diabetic fatty rats, a model of IGT (impaired glucose tolerance)[3]. | Animal Model: | Zucker diabetic fatty rat[2] | | Dosage: | 25 mg/kg | | Administration: | Oral gavage; once daily | | Result: | Significantly improved the glucose tolerance in Zucker diabetic fatty rats.
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