| Chemical Properties | Back Directory | [Boiling point ]
528.6±50.0 °C(predicted) | [density ]
1.309±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
6.05±0.40(predicted) | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Uses]
(R)-(+)-O-Demethylbuchenavianine is an inhibitor for Cyclin-dependent kinases (CDK). (R)-(+)-O-Demethylbuchenavianine inhibits CDK1, CDK5, glycogen synthase kinase-3 (GSK3), cdc2-like kinase (CLK1) and dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A), with IC50s of 1.1, 0.95, >10, >10 and >10 μM, respectively[1]. | [IC 50]
CDK5: 0.95 μM (IC50); CDK1: 1.1 μM (IC50); CLK1; DYRK1A; GSK-3 | [References]
[1] Nguyen TB, et al., Synthesis, biological evaluation, and molecular modeling of natural and unnatural flavonoidal alkaloids, inhibitors of kinases. J Med Chem. 2012 Mar 22;55(6):2811-9. DOI:10.1021/jm201727w |
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