| Identification | Back Directory | [Name]
DHODH-IN-14 | [CAS]
1364791-93-4 | [Synonyms]
DHODH-IN-14
DHODH IN 14,DHODHIN14
1,2,5-Oxadiazole-3-carboxamide, 4,5-dihydro-4-oxo-N-(2,3,5,6-tetrafluoro[1,1'-biphenyl]-4-yl)- | [Molecular Formula]
C15H7F4N3O3 | [MDL Number]
MFCD32671347 | [MOL File]
1364791-93-4.mol | [Molecular Weight]
353.23 |
| Hazard Information | Back Directory | [Uses]
DHODH-IN-14 (Compound 7l) is a hydroxyfurazan analog of A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.49 μM for rat liver DHODH. DHODH-IN-14 can be used for rheumatoid arthritis[1]. | [References]
[1] Lolli ML, et al. New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold. Eur J Med Chem. 2012 Mar;49:102-9. DOI:10.1016/j.ejmech.2011.12.038 |
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