| Identification | Back Directory | [Name]
E67-2 | [CAS]
1364914-62-4 | [Synonyms]
E67-2
2,4-Quinazolinediamine, 7-[(5-aminopentyl)oxy]-N2-[3-(dimethylamino)propyl]-6-methoxy-N4,N4-dimethyl- | [Molecular Formula]
C21H36N6O2 | [MDL Number]
MFCD34469369 | [MOL File]
1364914-62-4.mol | [Molecular Weight]
404.55 |
| Hazard Information | Back Directory | [Uses]
E67-2, as the E67 derivative, is a low-toxicity, selective KIAA1718 Jumonji domain inhibitor with an IC50 value of 3.4 μM. E67-2 selectively inhibits histone H3 lysine 9 (H3K9) Jumonji demethylase as well as histone H3 lysine 4 (H3K4) demethylase[1]. | [References]
[1] Upadhyay AK, et al. An analog of BIX-01294 selectively inhibits a family of histone H3 lysine 9 Jumonji demethylases. J Mol Biol. 2012;416(3):319-327. DOI:10.1016/j.jmb.2011.12.036 |
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