| Identification | Back Directory | [Name]
1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)- | [CAS]
136564-67-5 | [Synonyms]
LTD4 antagonist 1
1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)- | [Molecular Formula]
C31H32F3N3O5S | [MDL Number]
MFCD31544443 | [MOL File]
136564-67-5.mol | [Molecular Weight]
615.66 |
| Hazard Information | Back Directory | [Uses]
LTD4 antagonist 1 is a potent, orally active antagonist of leukotriene D4 (LTD4) with a Ki of 0.57 nM. | [in vivo]
LTD4 antagonist 1 (Compound 38b) exhibits a po ED50/iv ED50 of 1.44 and 0.036 μmol/kg in LTD4-induced bronchoconstriction in guinea pigs[1]. | [IC 50]
LTD4: 0.57 nM (Ki) | [References]
[1] Robert T. Jacobs, et al. Synthesis, Structure-Activity Relationships, and Pharmacological Evaluation of a Series of Fluorinated 3-Benzyl-5-Indolecarboxamides: Identification of 4-[[5-[((2R)-2-Methyl-4,4,4-trifluorobutyl)carbamoyl]-1-methylindol-3-yl]meth |
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