13659-23-9

108-43-0

13659-23-9

The general procedure for the synthesis of 2-bromo-5-chlorophenol using 3-chlorophenol as starting material was as follows: 5.03 g (39.1 mmol) of 3-chlorophenol was dissolved in 20 mL of dichloromethane, and the solution was cooled under ice bath conditions. Subsequently, 6.25 g (39.1 mmol) of bromine was added slowly and dropwise. The reaction mixture was gradually warmed to room temperature and stirred continuously for 16 hours. After completion of the reaction, the reaction mixture was diluted with water and phase separation was carried out. The organic phase was dried with magnesium sulfate. The residue was purified by silica gel column chromatography with an eluent ratio of 3:2 dichloromethane to hexane solvent mixture. The elution grade containing the target product 2-bromo-5-chlorophenol was collected and concentrated under reduced pressure to give 2.04 g (25% yield) of the pure product. High-resolution mass spectrometry (HRMS) results: calculated value of C6H4OClBr (M+) was 205.9134; measured value was 205.9125. Elemental analysis (EA) results: calculated value of C, 34.74; H, 1.94; measured value of C, 34.74; H, 1.76.