| Identification | Back Directory | [Name]
NS 102 | [CAS]
136623-01-3 | [Synonyms]
NS 102 solid
NS 102 (6,7,8,9-TETRAHYDRO-5-NITRO-1H-BE NZ(G)INDOLE-2,3-
5-nitro-6,7,8,9-tetrahydrobenzo(G)indole-2,3-dione-3-oxime
1H-Benz[g]indole-2,3-dione, 6,7,8,9-tetrahydro-5-nitro-, 3-oxime | [Molecular Formula]
C12H11N3O4 | [MOL File]
136623-01-3.mol | [Molecular Weight]
261.23 |
| Chemical Properties | Back Directory | [density ]
1.74±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: >3 mg/mL | [form ]
solid | [pka]
8.91±0.20(Predicted) | [color ]
yellow | [InChI]
1S/C12H11N3O4/c16-12-11(14-17)8-5-9(15(18)19)6-3-1-2-4-7(6)10(8)13-12/h5,17H,1-4H2,(H,13,14,16) | [InChIKey]
SCDBMLHUXJBJSS-UHFFFAOYSA-N | [SMILES]
O\N=C1/C(=O)Nc2c3CCCCc3c(cc12)[N+]([O-])=O |
| Hazard Information | Back Directory | [Uses]
NS-102 is a selective kainate (GluK2) receptor antagonist. NS-102 is a potent GluR6/7 receptor antagonist[1][2][3]. | [Definition]
ChEBI: NS-102 is a nitronaphthalene. | [Biochem/physiol Actions]
Competitive glutamate receptor antagonist with high selectivity for the low-affinity [3H] kainate binding site. | [in vivo]
NS-102 (20, 40 or 80?μM ; in the hippocampal CA3 region) significantly reduces Sevoflurane-induced hyperactivities[1]. | [storage]
Store at -20°C | [References]
[1] Selva Baltan Tekk?k, et al. Excitotoxic mechanisms of ischemic injury in myelinated white matter. J Cereb Blood Flow Metab. 2007 Sep;27(9):1540-52. DOI:10.1038/sj.jcbfm.9600455
[2] P Liang, et al. Sevoflurane activates hippocampal CA3 kainate receptors (Gluk2) to induce hyperactivity during induction and recovery in a mouse model. Br J Anaesth. 2017 Nov 1;119(5):1047-1054. DOI:10.1093/bja/aex043
[3] Barbara Gisabella, et al. Kainate receptor-mediated modulation of hippocampal fast spiking interneurons in a rat model of schizophrenia. PLoS One. 2012;7(3):e32483. DOI:10.1371/journal.pone.0032483 |
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