| Chemical Properties | Back Directory | [Boiling point ]
512.1±60.0 °C(Predicted) | [density ]
1.291±0.06 g/cm3(Predicted) | [solubility ]
Soluble to 100 mM in DMSO and to 20 mM in ethanol | [pka]
2.52±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
GSK 2833503A is a potent, and selective inhibitor of TRPC3/6 channels with IC50 of 4 nM/5 nM, respectively. It dispalys >100-fold selectivity over other calcium-permeable channels. It has 100-fold greater potency for TRPC3 compared with Pyr3. GSK 2833503A (dose-dependent) blocks cell hypertrophy signaling triggered by angiotensin II or endothelin-1 in HEK293T cells as well as in neonatal and adult cardiac myocytes. | [Uses]
TRPC3/6-IN-3 is a selective TRPC3/6 blocker. TRPC3/6-IN-3 can be used for the research of cardiovascular disease[1]. | [storage]
Store at -20°C | [References]
[1] Washburn DG, et al. The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4979-84. DOI:10.1016/j.bmcl.2013.06.047 |
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