| Identification | Back Directory | [Name]
ABACAVIR SULFATE | [CAS]
136777-48-5 | [Synonyms]
ZIAGEN
ABACAVIR SULPHATE
Abacavir (hydrochloride)
Abacavir & Abacavir Sulfate
((1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-enyl)methano
(4S)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopenten-1-yl]methanol,sulfuricaci
(1S-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol monohydrochloride | [Molecular Formula]
C28H38N12O6S | [MDL Number]
MFCD04112763 | [MOL File]
136777-48-5.mol | [Molecular Weight]
670.74 |
| Hazard Information | Back Directory | [Uses]
Abacavir hydrochloride is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir hydrochloride can inhibits the replication of HIV. Abacavir hydrochloride shows anticancer activity in prostate cancer cell lines. Abacavir hydrochloride can trespass the blood-brain-barrier and suppresses telomerase activity[1][2][3]. | [Definition]
ChEBI: Abacavir sulfate is an azaheterocycle sulfate salt that is the sulfate salt of the HIV-1 reverse transcriptase inhibitor abacavir. It is functionally related to an abacavir. | [in vivo]
Abacavir hydrochloride (100 and 200 mg/kg, p.o.; 4 h) dose-dependently promotes thrombus formation[2].
Abacavir hydrochloride (50 mg/kg/d; i.p.; 14 d) with 0.1 mg/kg/d Decitabine.html" class="link-product" target="_blank">Decitabine (HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice[3]. | Animal Model: | Male mice (9-weeks old, 22-30 g) - wild-type (WT) C57BL/6 or homozygous knockout (P2rx7 KO, B6.129P2-P2rx7tm1Gab/J)[2] | | Dosage: | Route 1: 2.5, 5, and 7.5 μg/mL, 100 μL
Route 2: 100 and 200 mg/kg | | Administration: | Intrascrotal or oral administration for 4 h | | Result: | Dose-dependently promoted thrombus formation.
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| Animal Model: | NSGTM mice, patient-derived xenograft (PDX) cells of non-WNT/non-SHH, Group 3 and of SHH/ TP53-mutated medulloblastoma[3] | | Dosage: | 50 mg/kg/d with 0.1 mg/kg/d Decitabine | | Administration: | Intraperitoneal injection, daily for 14 days | | Result: | Inhibited tumor growth and enhanced mouse survival.
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| [References]
[1] Carlini F, et al. The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines. PLoS One. 2010 Dec 3;5(12):e14221. DOI:10.1371/journal.pone.0014221
[2] Collado-Diaz V, et al. Abacavir Induces Arterial Thrombosis in a Murine Model. J Infect Dis. 2018 Jun 20;218(2):228-233. DOI:10.1093/infdis/jiy001
[3] Gringmuth M, et al. Enhanced Survival of High-Risk Medulloblastoma-Bearing Mice after Multimodal Treatment with Radiotherapy, Decitabine, and Abacavir. Int J Mol Sci. 2022 Mar 30;23(7):3815. DOI:10.3390/ijms23073815
[4] McComsey GA, et al. Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine. AIDS. 2005 Jan 3;19(1):15-23. DOI:10.1097/00002030-200501030-00002 |
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Lupin Ltd
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+91-8019896181 |
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www.lupin.com |
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