| Identification | Back Directory | [Name]
Retinyl β-D-glucoside | [CAS]
136778-12-6 | [Synonyms]
Retinyl glucoside
Retinyl β-D-glucoside
β-D-Glucopyranoside, 3,7-dimethyl-9-[(2E,4E,6E,8E)-2,6,6-trimethyl-1-cyclohexen-1-yl]-2,4,6,8-nonatetraenyl
(2R,3R,4S,5S,6R)-2-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol | [Molecular Formula]
C26H40O6 | [MDL Number]
MFCD26960935 | [MOL File]
136778-12-6.mol | [Molecular Weight]
448.59 |
| Chemical Properties | Back Directory | [Boiling point ]
626.3±55.0 °C(Predicted) | [density ]
1.15±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
12.88±0.70(Predicted) | [color ]
Yellow to brown |
| Hazard Information | Back Directory | [Uses]
Retinyl-β-D-glucoside is a naturally occurring and biologically active metabolites of vitamin A, which are found in fish and mammals.
IC50 Value:
Target:
in vitro: Retinyl beta-D-glucoside is a substrate for two broad-specificity mammalian beta-glucosidases, namely the cytosolic and membrane-associated beta-glucosidases of guinea pig liver. However, retinyl beta-D-glucoside is not hydrolysed by placental glucocerebrosidase [1].
in vivo: Depending on the mode of administration, retinyl beta-glucose, which is soluble in water, showed 67-100% of the growth-promoting activity of retinyl acetate in vitamin A-deficient rats. In metabolic studies on vitamin A-deficient rats, retinyl beta-glucose was rapidly hydrolyzed to retinol [2]. | [storage]
Store at -20°C | [References]
[1] Vanderjagt DJ, et al. Human glucocerebrosidase catalyses transglucosylation between glucocerebroside and retinol. Biochem J. 1994 Jun 1;300 ( Pt 2):309-15. http://www.ncbi.nlm.nih.gov/pubmed/8002933 DOI:10.1042/bj3000309
[2] Barua AB, et al. Chemical synthesis, growth-promoting activity, and metabolism of all-trans retinyl beta-glucose in the rat. Int J Vitam Nutr Res. 1992;62(4):298-302. PMID:1291531 |
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