| Identification | Back Directory | [Name]
Naphtho[1,2-d]thiazol-2-amine, 5-methyl- | [CAS]
1369170-24-0 | [Synonyms]
SKA-111
Naphtho[1,2-d]thiazol-2-amine, 5-methyl- | [Molecular Formula]
C12H10N2S | [MOL File]
1369170-24-0.mol | [Molecular Weight]
214.29 |
| Chemical Properties | Back Directory | [Boiling point ]
427.0±38.0 °C(Predicted) | [density ]
1.348±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.74±0.30(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
SKA-111 is a positive KCa channel gating modulator with selectivity for KCa3.1. | [Uses]
SKA-111 is a selective activator of potassium phannel KCa 3.1 , evokes KCa 3.1 membrane hyperpolarization in porcine endothelial cell. SKA-111 is capable of improving Bradykinin (HY-P0206)-induced coronary dilations in the isolated rat heart and can be used for cardiovascular disease research[1]. | [in vivo]
SKA-111 (1 μM for cardiac perfusion) improves Bradykinin (HY-P0206)-induced coronary dilations in the isolated rat heart[1].
| Animal Model: | Langendorff in rat hearts [1] | | Dosage: | 1 μM | | Administration: | Cardiac perfusion | | Result: | Potentiated significantly the fall in coronary perfusion pressure (CPP) induced by 1 nM BK in the presence of the vasoconstrictor in isolated rat hearts.
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| [References]
[1] Oliván-Viguera A, et.al. Vascular Reactivity Profile of Novel KCa 3.1-Selective Positive-Gating Modulators in the Coronary Vascular Bed. Basic Clin Pharmacol Toxicol. 2016 Aug;119(2):184-92. DOI:10.1111/bcpt.12560 |
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